https://www.hebertresearchgroup.com/science daily 0.75 2024-09-25 https://www.hebertresearchgroup.com/science/introduction-to-antibody-drug-conjugates monthly 0.5 2024-09-07 https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/76253900-6f09-4618-aa0a-9c318695bda2/AstraZeneca.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/8b0f26e5-c47c-454d-92a0-5c8e1122ef88/Traditional+chemo+compounds+v2.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Figure 1. Overview of Chemotherapeutic Medicines. Examples of commonly used medicines and their mechanism of action. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/9f6d022d-4be7-49b8-a9bb-5fd5e277cd28/Pfizer.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/37a3ea29-e339-4219-91cb-9362f4ae757e/AbbVie.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/a15f1f38-880f-44a7-acdd-6c4cdb9fc739/Endosomal+release.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Figure 6. Endosomal Release of Toxin Payload From an ADC. Confined within the endosome, proteases and a low pH environment work in tandem to cleave the ADC linker moiety and degrade the antibody. This frees the chemotherapy to diffuse into the cytosol or nucleus and exert its lethal effects. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/41314c5f-6a0f-43bd-80f4-e06a98cf1ed5/ADC+-+TLR+and+ASO.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Figure 8. Novel ADC Formats. Exploratory payloads include immune stimulating compounds such as TLR agonists or nucleic acid therapeutics such as ASOs. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/73f6ba17-0919-4f12-8458-843660f22863/Therapeutic+window.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Figure 2. Schematic of Therapeutic Index. Representative dose-response curves showing the relationship between drug dose, efficacy, and toxicity. The wider the gap between a therapeutic dose of a compound and a toxic dose, the greater the therapeutic index. ADCs were designed to expand the safety and efficacy of chemotherapy https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/a5f3cb8d-31b8-4920-8990-7c3ccd872aee/ADC+on+cancer+cell.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Figure 4. ADCs Specifically Target Cancer Cells. The antibody portion of the ADC binds to cell-surface proteins uniquely expressed on cancerous tissues, enabling precise delivery to malignant cells while sparing healthy counterparts. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/92ea4da1-d2ba-4260-933d-0d589a825689/Approved+ADCs.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Figure 7. List of Currently FDA Approved ADCs. The medicines treat a wide range of liquid and solid tumors. * = following market withdrawal in 2010, Mylotarg was FDA approved in 2017 using a modified dose. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/e13142b9-cd85-4514-a663-437dbfcbb45e/Merck.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/9cde87dd-c762-416f-9bf9-4c9e55783ba6/Receptor-mediated+endocytosis.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Figure 5. ADC Uptake by Endocytosis. Upon binding its specific cell-surface receptor, an ADC is internalized via receptor mediated-endocytosis into an endosome. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/06c04903-dc38-4e59-bc92-b42d1e9f829c/IgG+vs+ADC.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Figure 3. Structure of Human IgG Compared to an ADC. Fusing a chemotherapy to a human antibody (IgG) via a selectively cleavable linker is the most common form of ADC. There are multiple copies of drug molecules on a single antibody, also known as the drug-antibody ratio (DAR). https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/dbe90442-02a2-4e02-8746-698596a8d8f3/Daiichi-Sankyo.png Science - Introduction to Antibody-Drug Conjugates - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.hebertresearchgroup.com/science/category/Education monthly 0.5 https://www.hebertresearchgroup.com/science/category/Analysis monthly 0.5 https://www.hebertresearchgroup.com/science/category/Primer monthly 0.5 https://www.hebertresearchgroup.com/science/tag/ADCs monthly 0.5 https://www.hebertresearchgroup.com/investing-journal daily 0.75 2024-09-18 https://www.hebertresearchgroup.com/investing-journal/my-portfolio-and-investing-philosophy monthly 0.5 2024-09-18 https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/d306e9bb-ab07-4c83-9240-b57d9d47d81b/Figure+1+-+Pie+chart.png Investing Journal - My Portfolio and Investing Philosophy - Make it stand out Figure 1. Snapshot of my portfolio. https://www.hebertresearchgroup.com/investing-journal/pfizer-rejuvenated-innovation-at-a-discount monthly 0.5 2024-09-18 https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/0c27e535-ae52-43f3-b6d5-8ef44128a737/Figure+1+-+stock+chart.png Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 1. Pfizer stock price over trailing 5-years. Source: Yahoo Finance. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/23fbbe0c-a015-43ef-b32f-073e8667c5ee/Figure+4+%2B+5+combo.png Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 4. Pfizer New Pipeline Modalities. Source: HRG and adapted from Figure 3 Wu, S.S., et al., Reviving an R&D pipeline: a step change in the Phase II success rate. Drug Discov Today, 2021. 26(2): p. 308-314. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/c3730fc5-964c-45c9-ad39-90c083246df2/Figure+2+-+Historical+success+rates+2010-2019.jpeg Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 2. Pfizer Phase II & III Success Rates, 2010-2019. Source: Figure 1 from Wu, S.S., et al., Reviving an R&D pipeline: a step change in the Phase II success rate. Drug Discov Today, 2021. 26(2): p. 308-314. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/d64c75c4-c29b-47f7-b6c8-4294caa7d997/Figure+13+-+2Q24+-+slide+8.png Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 8. Pipeline Medicines with Exciting Potential. Source: Pfizer 2Q24 Earnings Presentation. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/2a988584-0689-4c2f-bc30-cdafc82de1dc/Figure+6+-+FIH+to+approval+succes+rate+-+Fernando%2C+K.+et+al+2022.jpeg Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 5. Clinical Success Rates vs Industry, 2016-2021. Rates are shown as a rolling average over 3 or 5-years. A) Cumulative FIH to approval. B) Phase I to phase II transition. C) Phase II to phase III transition. D) Phase III to approval. Source: Figure 1 from Fernando, K., et al., Achieving end-to-end success in the clinic: Pfizer's learnings on R&D productivity. Drug Discov Today, 2022. 27(3): p. 697-704. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/e47c9119-5f82-4e18-a47c-e0fdfd21ef93/Finance+figure+combo.png Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 9. Pfizer Consensus EPS Estimates and Historical Dividends per Share. Source: Yahoo Finance. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/04d11a4e-e5f6-4a61-8bc3-e0d28ecf7c62/Figure+12+%2B+.png Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 8. Seagen Acquisition Rationale and Projected Revenue Impact. Source: Pfizer 2Q23 Earnings Presentation and Proposed Seagen Acquisition Slides. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/20ad9b26-ce2d-4045-91ae-dfddc7a84367/Figure+3+-+Phase+II+NME+success+rates+by+TA+-+Wu%2C+S.S.+et+al+2021.jpeg Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 3. Pfizer Phase II Success Rates by Treatment Area. Source: Figure 2 from Wu, S.S., et al., Reviving an R&D pipeline: a step change in the Phase II success rate. Drug Discov Today, 2021. 26(2): p. 308-314. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/33efa68f-e6d2-4106-bb77-12b2fc06355e/Figure+8+%2B+9+combo.png Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 6. 2025-2030 Revenue Projections and LOEs. Source. Pfizer 2Q23 Earnings Presentation. https://images.squarespace-cdn.com/content/v1/669e87efd584d341b275fe7d/01579330-83ae-43ca-9e9c-ef98d8b11b54/Figure+10+%2B+11+combo.png Investing Journal - Pfizer: Rejuvenated Innovation Engine at a Discount - Make it stand out Figure 7. Newly Launched Products and Recent Acquisitions. 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